COMPARATIVE STUDY
JOURNAL ARTICLE
RANDOMIZED CONTROLLED TRIAL
RESEARCH SUPPORT, NON-U.S. GOV'T
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Early vs interval appendectomy for children with perforated appendicitis.

OBJECTIVE: To compare the effectiveness and adverse event rates of early vs interval appendectomy in children with perforated appendicitis.

DESIGN: Nonblinded randomized trial.

SETTING: A tertiary-referral urban children's hospital.

PATIENTS: A total of 131 patients younger than 18 years with a preoperative diagnosis of perforated appendicitis.

INTERVENTIONS: Early appendectomy (within 24 hours of admission) vs interval appendectomy (6-8 weeks after diagnosis).

MAIN OUTCOME MEASURES: Time away from normal activities (days). Secondary outcomes included the overall adverse event rates and the rate of predefined specific adverse events (eg, intra-abdominal abscess, surgical site infection, unplanned readmission).

RESULTS: Early appendectomy, compared with interval appendectomy, significantly reduced the time away from normal activities (mean, 13.8 vs 19.4 days; P < .001). The overall adverse event rate was 30% for early appendectomy vs 55% for interval appendectomy (relative risk with interval appendectomy, 1.86; 95% confidence interval, 1.21-2.87; P = .003). Of the patients randomized to interval appendectomy, 23 (34%) had an appendectomy earlier than planned owing to failure to improve (n = 17), recurrent appendicitis (n = 5), or other reasons (n = 1).

CONCLUSIONS: Early appendectomy significantly reduced the time away from normal activities. The overall adverse event rate after early appendectomy was significantly lower compared with interval appendectomy.

TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00435032.

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