We have located links that may give you full text access.
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
18F-FDG PET/CT and 123I-metaiodobenzylguanidine imaging in high-risk neuroblastoma: diagnostic comparison and survival analysis.
Journal of Nuclear Medicine 2011 April
UNLABELLED: The aim of our study was to evaluate prospectively the diagnostic performance and prognostic significance of (18)F-FDG PET/CT in comparison with (123)I-metaiodobenzylguanidine ((123)I-MIBG) imaging in patients with high-risk neuroblastoma.
METHODS: Twenty-eight patients with refractory or relapsed high-risk neuroblastoma (16 male and 12 female patients; age range, 2-45 y; median age, 7.5 y) were simultaneously evaluated with (18)F-FDG PET/CT and (123)I-MIBG imaging before treatment with high-dose (131)I-MIBG. We compared the 2 methods in mapping tumor load, according to the extent of disease and intensity of positive lesions identified in each patient. Separate comparisons were performed for the soft-tissue and bone-bone marrow components of tumor burden. Survival analysis was performed to assess the prognostic significance of (18)F-FDG and (123)I-MIBG imaging parameters.
RESULTS: (18)F-FDG PET/CT results were positive in 24 of 28 (86%) patients, whereas (123)I-MIBG imaging results were positive in all patients. (18)F-FDG was superior in mapping tumor load in 4 of 28 (14%) patients, whereas (123)I-MIBG was better in 12 of 28 (43%) patients. In the remaining 12 (43%) patients, no major differences were noted between the 2 modalities. (18)F-FDG PET/CT missed 5 cases of bone-bone marrow disease, 4 cases of soft-tissue disease, and 6 cases of skull involvement that were positive on (123)I-MIBG scans. Cox regression and Kaplan-Meier survival curves showed that the group of patients (4/28) in whom (18)F-FDG was superior to (123)I-MIBG had a significantly lower survival rate than the others. Tumoral avidity for (18)F-FDG (maximum standardized uptake value) and extent of (18)F-FDG-avid bone-bone marrow disease were identified as adverse prognostic factors.
CONCLUSION: (123)I-MIBG imaging is superior to (18)F-FDG PET/CT in the assessment of disease extent in high-risk neuroblastoma. However, (18)F-FDG PET/CT has significant prognostic implications in these patients.
METHODS: Twenty-eight patients with refractory or relapsed high-risk neuroblastoma (16 male and 12 female patients; age range, 2-45 y; median age, 7.5 y) were simultaneously evaluated with (18)F-FDG PET/CT and (123)I-MIBG imaging before treatment with high-dose (131)I-MIBG. We compared the 2 methods in mapping tumor load, according to the extent of disease and intensity of positive lesions identified in each patient. Separate comparisons were performed for the soft-tissue and bone-bone marrow components of tumor burden. Survival analysis was performed to assess the prognostic significance of (18)F-FDG and (123)I-MIBG imaging parameters.
RESULTS: (18)F-FDG PET/CT results were positive in 24 of 28 (86%) patients, whereas (123)I-MIBG imaging results were positive in all patients. (18)F-FDG was superior in mapping tumor load in 4 of 28 (14%) patients, whereas (123)I-MIBG was better in 12 of 28 (43%) patients. In the remaining 12 (43%) patients, no major differences were noted between the 2 modalities. (18)F-FDG PET/CT missed 5 cases of bone-bone marrow disease, 4 cases of soft-tissue disease, and 6 cases of skull involvement that were positive on (123)I-MIBG scans. Cox regression and Kaplan-Meier survival curves showed that the group of patients (4/28) in whom (18)F-FDG was superior to (123)I-MIBG had a significantly lower survival rate than the others. Tumoral avidity for (18)F-FDG (maximum standardized uptake value) and extent of (18)F-FDG-avid bone-bone marrow disease were identified as adverse prognostic factors.
CONCLUSION: (123)I-MIBG imaging is superior to (18)F-FDG PET/CT in the assessment of disease extent in high-risk neuroblastoma. However, (18)F-FDG PET/CT has significant prognostic implications in these patients.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Diagnosis and Management of Cardiac Sarcoidosis: A Scientific Statement From the American Heart Association.Circulation 2024 April 19
Essential thrombocythaemia: A contemporary approach with new drugs on the horizon.British Journal of Haematology 2024 April 9
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app