Primary anetoderma: a cutaneous marker of antiphospholipid antibodies.

Primary anetoderma is a rare idiopathic disease of the skin characterized by circumscribed areas of slack skin and loss of elastic fibers found on histopathologic examination. It has been related to systemic lupus erythematosus and other immune diseases. In recent years, however, its association with antiphospholipid antibodies has been highlighted, and it should be considered a clinical manifestation of these antibodies.