JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
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Variants of the WNT7A gene in Chinese patients with müllerian duct abnormalities.

OBJECTIVE: To search for WNT7A gene mutations in a cohort of 191 Chinese Han patients with müllerian duct abnormalities (MDAs).

DESIGN: Phenotypic and mutational study.

SETTING: University hospital.

PATIENT(S): A total of 191 Chinese Han patients with MDAs and 192 healthy control individuals.

INTERVENTION(S): Genomic DNA extracted from blood samples, all coding regions amplified by polymerase chain reaction (PCR) then directly sequenced to screen variants.

MAIN OUTCOME MEASURE(S): Not applicable.

RESULT(S): The sequence analysis revealed one novel synonymous variant and three known single-nucleotide polymorphisms (SNPs).

CONCLUSION(S): The results indicate that mutations in the coding sequence of WNT7A are not responsible for müllerian duct abnormalities in the Chinese population.

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