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Journal Article
Research Support, Non-U.S. Gov't
CO(2) laser surgery in elderly patients with glottic carcinoma: univariate and multivariate analyses of results.
Head & Neck 2012 December
BACKGROUND: There are limited data on the role of laser-assisted surgery for early glottic cancer in elderly patients.
METHODS: This retrospective study was conducted on a series of 130 consecutive cases of early glottic carcinoma occurring in elderly patients (>65 years old) treated with CO(2) laser surgery.
RESULTS: The overall and disease-specific survival rates were 87.7% and 99.2%, respectively. The rates of local disease control after primary laser surgery, ultimate local control with laser alone, and laryngeal preservation were 84.6%, 93.8%, and 96.9%, respectively. A shorter disease-free survival (DFS) was associated with the involvement of 1 or more specific laryngeal regions (arytenoids, ventricle, anterior commissure, vocal muscle, subglottis) (p = .01) and the status of the surgical margins (p = .002); on multivariate analysis, only the latter remained prognostically significant vis-à-vis the DFS (p = .002).
CONCLUSIONS: Even in elderly patients with early glottic carcinoma, endoscopic laser surgery is an effective treatment.
METHODS: This retrospective study was conducted on a series of 130 consecutive cases of early glottic carcinoma occurring in elderly patients (>65 years old) treated with CO(2) laser surgery.
RESULTS: The overall and disease-specific survival rates were 87.7% and 99.2%, respectively. The rates of local disease control after primary laser surgery, ultimate local control with laser alone, and laryngeal preservation were 84.6%, 93.8%, and 96.9%, respectively. A shorter disease-free survival (DFS) was associated with the involvement of 1 or more specific laryngeal regions (arytenoids, ventricle, anterior commissure, vocal muscle, subglottis) (p = .01) and the status of the surgical margins (p = .002); on multivariate analysis, only the latter remained prognostically significant vis-à-vis the DFS (p = .002).
CONCLUSIONS: Even in elderly patients with early glottic carcinoma, endoscopic laser surgery is an effective treatment.
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