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In vitro activities of the new antitubercular agents PA-824 and BTZ043 against Nocardia brasiliensis.
Antimicrobial Agents and Chemotherapy 2012 July
The in vitro activity of PA-824 and BTZ043 against 30 Nocardia brasiliensis isolates was tested. The MIC(50) and MIC(90) values for PA-824 were both >64 μg/ml. The same values for BTZ043 were 0.125 and 0.250 μg/ml. Given the MIC values for benzothiazinone (BTZ) compounds, we consider them good candidates to be tested in vivo against N. brasiliensis.
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