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Asthma drugs and the risk of congenital anomalies.
Pharmacotherapy 2013 April
STUDY OBJECTIVE: To estimate the prevalence of congenital anomalies between the offspring of women exposed and unexposed to asthma drugs during early pregnancy.
DESIGN: Matched cohort study.
DATABASE: The United Kingdom's General Practice Research Database.
PATIENTS: Women exposed to asthma drugs during early pregnancy and a sample of matched unexposed pregnant women.
MEASUREMENTS AND MAIN RESULTS: The prevalence of any anomaly among unexposed and exposed women was 27.8 (95% confidence interval [CI] 25.4-30.6)/1000 pregnancies and 31.3 (95% CI 27.7-35.5)/1000 pregnancies, respectively (relative risk [RR] 1.1 95% CI 1.0-1.3).
CONCLUSION: Our findings suggest that asthma drugs, overall, do not increase the risk of congenital anomalies in the offspring when taken during the first trimester of pregnancy.
DESIGN: Matched cohort study.
DATABASE: The United Kingdom's General Practice Research Database.
PATIENTS: Women exposed to asthma drugs during early pregnancy and a sample of matched unexposed pregnant women.
MEASUREMENTS AND MAIN RESULTS: The prevalence of any anomaly among unexposed and exposed women was 27.8 (95% confidence interval [CI] 25.4-30.6)/1000 pregnancies and 31.3 (95% CI 27.7-35.5)/1000 pregnancies, respectively (relative risk [RR] 1.1 95% CI 1.0-1.3).
CONCLUSION: Our findings suggest that asthma drugs, overall, do not increase the risk of congenital anomalies in the offspring when taken during the first trimester of pregnancy.
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