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Keratin Expression in Mammary Paget's Disease in situ with Intraductal Invasion.

Ichiro Kurokawa, Sayaka Furukawa, Masahiro Kishimoto, Ayako Kakuno, Airo Tsubura
Case Reports in Oncology 2012 May
We performed immunohistochemical studies of epithelial keratins in intraductal carcinoma in situ (IDCIS) in mammary Paget's disease (MPD). K7, K8 and K18 were expressed in IDCIS in MPD. However, K19 was not expressed in IDCIS in MPD. Interestingly, K17 was expressed in some tumor cells in IDCIS. K17, a hyperproliferative keratin, may suggest ductal invasion and poor prognosis in MPD.

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