Meta-analysis of the effect of intravitreal bevacizumab in branch retinal vein occlusion.

BACKGROUND: To further evaluate the effect of intravitreal bevacizumab (IVB) for the treatment of branch retinal vein occlusion in a meta-analysis of previous studies.

METHODS: Pertinent publications were identified through systemic searches of PubMed, EMBASE, and the Cochrane Controlled Trials Register up to July 2012. Data on central macular thickness and best-corrected visual acuity obtained at 4 and 12 weeks after treatment were extracted. Groups of patients receiving IVB were compared with control groups.

RESULTS: Four randomized controlled and 3 comparative studies were included. A publication bias was not detected by funnel plots, the Egger method, or the Begg method. Best corrected visual acuity measured at 4 and 12 weeks after baseline increased significantly in the IVB groups as compared with the control groups [4 weeks: weighted mean deviation (WMD)=-0.09; 95% confidence interval (CI): -0.12, -0.05; P<0.001; at 12 weeks: WMD=-0.21; 95% CI: -0.30, -0.12; P<0.001]. Similarly, reduction in central macular thickness at 12 weeks after baseline was significantly higher in the IVB groups than in the control groups (WMD=-29.02; 95% CI: -50.56, -7.49; P=0.008). The change in central macular thickness at 4 weeks after baseline did not vary significantly between the IVB groups and control groups (WMD=-20.48; 95% CI: -67.30, 26.34; P=0.39). All included studies taken separately reported on a significant increase in visual acuity in the IVB groups.

CONCLUSIONS: Patients with branch retinal vein occlusion experienced a significant benefit in terms of visual improvement and reduction in central macular thickness after the intravitreal injection of bevacizumab.