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Investigational drug available directly from CDC for the treatment of infections with free-living amebae.

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MMWR. Morbidity and Mortality Weekly Report 2013 August 24
Infections caused by free-living amebae (FLA) are severe and life-threatening. These infections include primary amebic meningoencephalitis (PAM) caused by Naegleria fowleri and granulomatous amebic encephalitis caused by Balamuthia mandrillaris and Acanthamoeba species. Although several drugs have in vitro activity against FLA, mortality from these infections remains>90% despite treatment with combinations of drugs.

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