Enhanced glucagon-like peptide-1 secretion in a patient with glucagonoma: implications for glucagon-like peptide-1 secretion from pancreatic α cells in vivo.

Daisuke Yabe, Mariyo Rokutan, Yoshiyuki Miura, Izumi Komoto, Ryota Usui, Hitoshi Kuwata, Koin Watanabe, Takanori Hyo, Takeshi Kurose, Terumi Nagamatsu, Shinobu Shimizu, Jun Kawai, Masayuki Imamura, Yutaka Seino

Diabetes Research and Clinical Practice 2013 October

We examined GLP-1 secretion from the pancreas of a patient with glucagonoma and pancreatic resection by measuring GLP-1 after meal ingestion or selective arterial calcium injection, and immunohistochemical analysis. Our findings support the notion that GLP-1 is secreted from pancreatic α cells in humans.

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