CASE REPORTS
JOURNAL ARTICLE
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123I-ioflupane SPECT findings of pantothenate kinase-associated neurodegeneration.

We present a case of a 72-year-old man with a 9-year history of memory decline and 7-year history of parkinsonian symptoms. An MRI demonstrated an "eye-of-the-tiger" sign in the basal ganglia, suggestive of pantothenate kinase-associated neurodegeneration (formerly known as Hallervorden-Spatz syndrome). An 123I-ioflupane SPECT scan demonstrated absence of radiotracer uptake in the caudate nuclei and putamina. Genetic testing confirmed a single-point mutation in the PANK2 gene, consistent with pantothenate kinase-associated neurodegeneration.

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