Inhibition of xanthine oxidase and exercise on serum uric acid, 25(OH)D3, and calcium concentrations.

BACKGROUND: It has been shown that serum concentrations of 1,25(OH)2D3 are decreased in patients with gout. A short-term administration of allopurinol increases plasma concentrations of 1,25(OH)2D3 in mild to moderate renal failure, with or without hyperuricemia. It has been reported that subjects who perform regular vigorous and/ or moderate physical activities have higher plasma and serum 25(OH)D3 levels. However, little is known about the influence of allopurinol and/or physical exercise on serum 25(OH)D3 concentrations in humans.

METHODS: We investigated the effect of allopurinol administration and/or physical activity on vitamin D metabolism by measuring serum uric acid, 25(OH)D3, and calcium levels in twelve professional soccer players.

RESULTS: The athletes supplemented with allopurinol, but not those who received placebo, exhibited a significant decrease in uric acid serum concentrations after the match. We also found a significant increase in serum calcium and 25(OH)D3 concentrations in the supplemented group.

CONCLUSIONS: We conclude that allopurinol administration might be an effective drug to lower hyperuricemia and treat hypovitaminosis D.