Prospective study of the safety and efficacy of intermittent inflow occlusion (Pringle maneuver) in living donor left hepatectomy.

AIM: The impact of intermittent inflow occlusion (Pringle maneuver) in living donor hepatectomy on the outcome of both the donor and the recipient is unknown. The aim of this study is to elucidate the safety and efficacy of Pringle maneuver in living donor hepatectomy.

METHODS: Twenty consecutive cases of living donors who underwent left hepatectomy were prospectively divided into two groups, with (Group A, n = 10) or without (Group B, n = 10) the Pringle maneuver during hepatectomy. Intraoperative blood loss, postoperative liver functions in the donors and recipient outcome were reviewed.

RESULTS: Median blood loss was significantly less in group A than in group B. Median alanine aminotransferase was significantly higher on postoperative day 1 in group A than in group B, but the difference was not significant at 7 days after surgery. Eight of 10 recipients in each group survived with good graft function with a median follow-up period of 20 months in group A and 19 months in group B.

CONCLUSION: The Pringle maneuver was safely applied in living donor hepatectomy, but the only benefit was the reduction of blood loss during the donor surgery, and no positive impact on the recipient outcome.