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Journal Article
Research Support, Non-U.S. Gov't
Morphometry of the trochlear nerve and superior oblique muscle volume in congenital superior oblique palsy.
Investigative Ophthalmology & Visual Science 2014 November 21
PURPOSE: To infer the pathogenic mechanism of congenital superior oblique palsy (SOP) by evaluating trochlear nerve diameter (CN4D) and superior oblique muscle (SO) volume in patients with congenital SOP.
METHODS: The medical records of 125 patients diagnosed with unilateral congenital SOP and 34 age-matched healthy controls were reviewed retrospectively. Using thin-section high-resolution magnetic resonance imaging, we evaluated the presence of the trochlear nerve, CN4D, SO volume, and their relationship.
RESULTS: Of the 125 patients with congenital SOP, 87 showed absence of the trochlear nerve (n = 87, 70%, absent group) and 38 showed bilateral presence of the trochlear nerve (n = 38, 30%, present group). The nonparetic side CN4D was smaller than controls in the absent group (P = 0.001), and larger than controls in the present group (P = 0.001). Trochlear nerve diameter positively correlated with SO volume in controls (P = 0.014, R(2) = 0.174) and in the nonparetic sides of congenital SOP (present group P = 0.023, R(2) = 0.135; absent group, P = 0.008, R(2) = 0.079). The paretic side SO volume did not show a linear correlation between CN4D and SO volume in the present group (P = 0.243).
CONCLUSIONS: In congenital SOP patients without a trochlear nerve, the nonparetic side CN4D was also reduced in contrast to those with a trochlear nerve. The relatively weaker relationship of CN4D and nonparetic side SO volume in the absent group than that of the present group suggests different pathogenic mechanisms underlying these two entities of congenital SOP.
METHODS: The medical records of 125 patients diagnosed with unilateral congenital SOP and 34 age-matched healthy controls were reviewed retrospectively. Using thin-section high-resolution magnetic resonance imaging, we evaluated the presence of the trochlear nerve, CN4D, SO volume, and their relationship.
RESULTS: Of the 125 patients with congenital SOP, 87 showed absence of the trochlear nerve (n = 87, 70%, absent group) and 38 showed bilateral presence of the trochlear nerve (n = 38, 30%, present group). The nonparetic side CN4D was smaller than controls in the absent group (P = 0.001), and larger than controls in the present group (P = 0.001). Trochlear nerve diameter positively correlated with SO volume in controls (P = 0.014, R(2) = 0.174) and in the nonparetic sides of congenital SOP (present group P = 0.023, R(2) = 0.135; absent group, P = 0.008, R(2) = 0.079). The paretic side SO volume did not show a linear correlation between CN4D and SO volume in the present group (P = 0.243).
CONCLUSIONS: In congenital SOP patients without a trochlear nerve, the nonparetic side CN4D was also reduced in contrast to those with a trochlear nerve. The relatively weaker relationship of CN4D and nonparetic side SO volume in the absent group than that of the present group suggests different pathogenic mechanisms underlying these two entities of congenital SOP.
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