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Evaluation Studies
Journal Article
Research Support, Non-U.S. Gov't
Sentinel lymph node biopsy in thick malignant melanoma: A 16-year single unit experience.
European Journal of Dermatology : EJD 2015 September
BACKGROUND: The role of sentinel lymph node biopsy (SLNB) and its benefits in patients with thick melanoma is still controversial.
OBJECTIVES: We evaluated the clinical effect of SLNB in patients with thick melanoma.
METHODS: We performed a retrospective cohort review (1996-2012) of thick melanomas. Collected data included the patient and tumour characteristics. Locoregional recurrence, distant metastases, disease free and overall survival were compared between the patients with positive and negative SLNB.
RESULTS: 126 thick melanomas with a mean age of 64.09 years were included in the study. Positive SLNB were found in 47 (37.3%) patients. Significantly more locoregional recurrence (P = 0.002) and distant metastases (P = 0.030) were detected in the patients with positive SLNB. Furthermore, the patients with negative SLNB showed significantly better disease free survival (P = 0.021).
CONCLUSIONS: Positive SLNB might be prognostic factor in thick melanoma and aggravates the outcome of thick melanomas.
OBJECTIVES: We evaluated the clinical effect of SLNB in patients with thick melanoma.
METHODS: We performed a retrospective cohort review (1996-2012) of thick melanomas. Collected data included the patient and tumour characteristics. Locoregional recurrence, distant metastases, disease free and overall survival were compared between the patients with positive and negative SLNB.
RESULTS: 126 thick melanomas with a mean age of 64.09 years were included in the study. Positive SLNB were found in 47 (37.3%) patients. Significantly more locoregional recurrence (P = 0.002) and distant metastases (P = 0.030) were detected in the patients with positive SLNB. Furthermore, the patients with negative SLNB showed significantly better disease free survival (P = 0.021).
CONCLUSIONS: Positive SLNB might be prognostic factor in thick melanoma and aggravates the outcome of thick melanomas.
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