We have located links that may give you full text access.
Journal Article
Review
The significance of the interictal spike discharge: a review.
This review deals with the significance of the interictal spike discharge (ISD) and the evidence that it is more than an epiphenomenon or an EEG curiosity. The ISD has a close but complex relationship to ictal activity, as exemplified by the epilepsia partialis continua that may appear with some periodic lateralized epileptiform discharges. The ISD correlates with the locus of the hypometabolic zones in positron emission tomography scans and a decreased rate of oxygen consumption, but there is an increase in glucose utilization and regional blood flow, in addition to changes in echo pulsation. The discharges may also be associated with cardiac arrhythmias, changes in free amino acids, and changes in prolactin level, and the discharges also may serve as a stimulus for a conditioned reflex. The effects of a cortical ISD may be long lasting and can be found in subcortical or other cortical regions, especially in the contralateral homologous area, where T1 spin echo changes can be seen, with effects also on spinal field potentials. In addition to behavioral changes, cognitive effects are clear, especially in determining a nonresponse, a long latency of response, or other types of transitory cognitive impairment, in which a given stimulus presented at the time of the discharge within the appropriate responding cortical area will impair the perception of that stimulus. An important example of the significance of these discharges is the impaired ability to operate an automobile, which may appear at the moment that the ISD occurs. Thus, the evidence is clear that the ISD is more than an EEG curiosity.
Full text links
Related Resources
Trending Papers
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Prevention and treatment of ischaemic and haemorrhagic stroke in people with diabetes mellitus: a focus on glucose control and comorbidities.Diabetologia 2024 April 17
Diagnosis and Management of Cardiac Sarcoidosis: A Scientific Statement From the American Heart Association.Circulation 2024 April 19
Eosinophilic Esophagitis: Clinical Pearls for Primary Care Providers and Gastroenterologists.Mayo Clinic Proceedings 2024 April
Essential thrombocythaemia: A contemporary approach with new drugs on the horizon.British Journal of Haematology 2024 April 9
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app