JOURNAL ARTICLE
REVIEW
Add like
Add dislike
Add to saved papers

Neoplasia arising in dysgenetic gonads.

We analyzed the clinicopathologic characteristics of 140 cases of neoplasia arising in dysgenetic gonads. These 140 cases were found on a review of the medical literature published between 1953 and 1983. The age of the patients at the time of diagnosis was recorded in 133 patients and ranged from 6 months to 45 years. The mean age at diagnosis was 18 years 8 months. Thirteen (9.8 per cent) patients were below the age of 10 at the time of diagnosis. A menstrual history was recorded in 109 cases. Amenorrhea was present in 103 (94.5 per cent). A Y chromosome or Y-chromosome fragment was present in 90.7 per cent of the 119 patients who had karyotype analysis. Bilateral tumors were found in 54 instances (38.6 per cent). Thus, a total of 194 neoplasms were found. Of these 103 (53.1 per cent) were gonadoblastomas, 38 (19.6 per cent) dysgerminomas, 34 (17.5 per cent), gonadoblastoma with areas of dysgerminoma, and 19 (9.8 per cent) were of other histologic types. Patients with dysgenetic gonads and Y chromosome material are at risk for development of ovarian neoplasm. A dysgerminoma of dysgerminomatous component was present in 37 per cent of the reviewed tumors. These neoplasms have been discovered as early as 6 months of age and 9.8 per cent of the cases occurred in patients below the age of 10. Early exploration and bilateral gonadectomy should be performed in patients with gonadal dysgenesis and Y-chromosome material in their karyotype.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app