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COMMENT
JOURNAL ARTICLE
RESEARCH SUPPORT, N.I.H., INTRAMURAL
HPV: CIB1 is for EVER and EVER.
Journal of Experimental Medicine 2018 September 4
In this issue, de Jong et al. (https://doi.org/10.1084/jem.20170308) identify bi-allelic loss-of-expression, loss-of-function mutations of the calcium- and integrin-binding protein 1 ( CIB1 ) gene as a new cause of epidermodysplasia verruciformis (EV) and demonstrate that the CIB1 interacts with the EVER1 and EVER2 proteins to form a complex involved in keratinocyte-intrinsic immune response to human β-papillomaviruses (β-HPVs).
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