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Five-year trends in multifocal electroretinogram for patients with birdshot chorioretinopathy.
American Journal of Ophthalmology 2018 December 15
PURPOSE: The aim of this study is to investigate temporal trends in multifocal ERG (mfERG) parameters and analyse their relationships with anatomical and functional markers in patients with Birdshot chorioretinopathy (BSCR).
DESIGN: Prospective observational case series METHODS: 16 BSCR patients were include and underwent two standardized follow-up (FU) visits within five years following a baseline examination, including mfERG, visual acuity (VA), visual field (VF), Lanthony desaturated panel D-15 test for color vision, quality of life (QoL), fluorescein and indocyanine green angiography, and optical coherence tomography (OCT).
RESULTS: A significant trend toward a decrease in absolute N1 amplitude values was observed over the follow-up period (P<.001) while N1 implicit time remained unchanged. In contrast, P1 amplitude decreased (P<.001) and P1 implicit time increased (P<.001) over the same period. No significant temporal change was found for VA, color vision score, foveal threshold, mean deviation of VF and QoL. After adjusting for time to FU, increasing N1 and P1 IT were both associated with decreasing values of LogMAR, foveal threshold, and QoL and with increasing color vision score, mean deviation of VF. A significant relationship was observed between decreasing P1 amplitude values and increasing mean deviation of VF. Lower absolute values of N1 amplitude were associated with venous vasculitis whereas lower P1 amplitude values correlated with alteration of the outer retina in OCT.
CONCLUSIONS: Progressive deterioration in mfERG during a 5-year period is detected in BSCR whereas classical functional test results were unchanged. This study suggests a better sensitivity of mfERG in monitoring the retinal function of BSCR patients.
DESIGN: Prospective observational case series METHODS: 16 BSCR patients were include and underwent two standardized follow-up (FU) visits within five years following a baseline examination, including mfERG, visual acuity (VA), visual field (VF), Lanthony desaturated panel D-15 test for color vision, quality of life (QoL), fluorescein and indocyanine green angiography, and optical coherence tomography (OCT).
RESULTS: A significant trend toward a decrease in absolute N1 amplitude values was observed over the follow-up period (P<.001) while N1 implicit time remained unchanged. In contrast, P1 amplitude decreased (P<.001) and P1 implicit time increased (P<.001) over the same period. No significant temporal change was found for VA, color vision score, foveal threshold, mean deviation of VF and QoL. After adjusting for time to FU, increasing N1 and P1 IT were both associated with decreasing values of LogMAR, foveal threshold, and QoL and with increasing color vision score, mean deviation of VF. A significant relationship was observed between decreasing P1 amplitude values and increasing mean deviation of VF. Lower absolute values of N1 amplitude were associated with venous vasculitis whereas lower P1 amplitude values correlated with alteration of the outer retina in OCT.
CONCLUSIONS: Progressive deterioration in mfERG during a 5-year period is detected in BSCR whereas classical functional test results were unchanged. This study suggests a better sensitivity of mfERG in monitoring the retinal function of BSCR patients.
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