Generalized Pustular Figurate Erythema. First Report in Two COVID-19 Patients on Hydroxychloroquine.

Generalized pustular figurate erythema (GPFE) is a distinctive severe cutaneous drug reaction with widespread urticarial or edematous plaques scattered over the entire body that become topped with non-follicular pustules that evolve into erythematous and sometimes atypical targetoid plaques converging into annular and arcuate patterns prominent on the trunk and extremities (1). It has been linked with medications, especially hydroxychloroquine. We describe two COVID-19 patients on hydroxychloroquine who developed this eruption 2 and 3 weeks after the onset of hydroxychloroquine. This report is the first to our knowledge of COVID-19 patients on hydroxychloroquine developing GPFE.