We have located links that may give you full text access.
Quinacrine treatment of nitroimidazole-refractory giardiasis.
Journal of Infectious Diseases 2021 May 25
BACKGROUND: Limited evidence exists on the efficacy and tolerability of quinacrine for nitroimidazole-refractory giardiasis.
METHODS: Nitroimidazole-refractory giardiasis cases, defined as microbiologically (microscopy and/or PCR) confirmed treatment failure after two courses, during 2008-2020, were retrospectively identified.
RESULTS: Of 87 patients, 54 (62%) had visited India. Quinacrine was used in 54 (62%); 51 received monotherapy and three combined with metronidazole. Only three had positive stool samples with persisting symptoms after quinacrine treatment (94% parasitological efficacy), and all were cured after a second treatment. One (1.9%) had mild adverse effects recorded.
CONCLUSIONS: Quinacrine is an effective treatment for nitroimidazole-refractory giardiasis with good tolerability.
METHODS: Nitroimidazole-refractory giardiasis cases, defined as microbiologically (microscopy and/or PCR) confirmed treatment failure after two courses, during 2008-2020, were retrospectively identified.
RESULTS: Of 87 patients, 54 (62%) had visited India. Quinacrine was used in 54 (62%); 51 received monotherapy and three combined with metronidazole. Only three had positive stool samples with persisting symptoms after quinacrine treatment (94% parasitological efficacy), and all were cured after a second treatment. One (1.9%) had mild adverse effects recorded.
CONCLUSIONS: Quinacrine is an effective treatment for nitroimidazole-refractory giardiasis with good tolerability.
Full text links
Related Resources
Trending Papers
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
British Society for Rheumatology guideline on management of adult and juvenile onset Sjögren disease.Rheumatology 2024 April 17
Albumin: a comprehensive review and practical guideline for clinical use.European Journal of Clinical Pharmacology 2024 April 13
Renin-Angiotensin-Aldosterone System: From History to Practice of a Secular Topic.International Journal of Molecular Sciences 2024 April 5
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app