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Exacerbation of acrodermatitis chronica atrophicans under antiretroviral treatment in an HIV infected patient.

Acrodermatitis chronica atrophicans (ACA) is a skin tertiary manifestation of Lyme disease which mainly results from long-lasting Borrelia afzelii infection. Diagnosis of ACA relies on clinical presentation and serologic testing. In challenging cases, histopathologic examination may be useful.1 Immune reconstitution inflammatory syndrome (IRIS) corresponds to the worsening of symptoms related to an infectious disease following the introduction of its treatment, or the correction of an underlying immunosuppression. It mainly occurs in human immunodeficiency virus (HIV)-infected patients following the introduction of antiretroviral therapy (ART).

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