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The UGT2A1/UGT2A2 locus is associated with COVID-19-related loss of smell or taste.

Janie F Shelton, Anjali J Shastri, Kipper Fletez-Brant, Stella Aslibekyan, Adam Auton
Nature Genetics 2022 Februrary
Using online surveys, we collected data regarding COVID-19-related loss of smell or taste from 69,841 individuals. We performed a multi-ancestry genome-wide association study and identified a genome-wide significant locus in the vicinity of the UGT2A1 and UGT2A2 genes. Both genes are expressed in the olfactory epithelium and play a role in metabolizing odorants. These findings provide a genetic link to the biological mechanisms underlying COVID-19-related loss of smell or taste.

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