Role of Platelet-Rich Plasma in the Treatment of Adhesive Capsulitis: A Prospective Cohort Study.

Background A glenohumeral (GH) joint disease, such as adhesive capsulitis, causes the shoulder capsule's fibrosis and adhesion to restrict mobility. Collagen and growth factors can be produced by platelet-rich plasma (PRP), which promotes stem cells and, as a result, improves the healing process. This study was done to determine the role of PRP injection in the treatment of adhesive capsulitis in terms of improvement in pain. Methodology This prospective cohort study was conducted at the Department of Orthopedics, Mayo Hospital, Lahore, Pakistan, from February 2022 to July 2022. A total of 305 patients were enrolled through the outpatient department. Basic demographic and clinical details, including the visual analog scale (VAS) pain score, were noted. First, 20 ml of the patient's blood was drawn from the superficial saphenous vein by double syringe. After processing, the PRP was collected and injected in the subacromial bursa and intra-articular space adopting the anatomical approach. Then, the process was repeated at weekly intervals for four weeks. In this phase, PRP was injected only in the joint. The pain was assessed before and after six weeks of treatment and improvement in pain as per VAS was noted. Results In a total of 305 cases, the mean age was 60.47±11.55 years. There were 164 (53.8%) male and 141 (46.2%) female cases. The mean pain VAS scores before and after treatment were 6.56±1.79 and 2.42±1.71, respectively, and the mean reduction in pain after treatment was 64.57±19.40%. In 267 (87.5%) cases, an improvement of ≥ 50% was observed while 38 (12.5%) cases had an improvement of <50%. Conclusion The PRP can be used for the treatment of adhesive capsulitis to reduce pain. This non-operative method of treatment may help reduce the hospital burden of patients suffering from adhesive capsulitis.