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Penicillin concentrations in serum following weekly injections of benzathine penicillin G.

H K Hagdrup, G Lange Wantzin, L Secher, V T Rosdahl
Chemotherapy 1986
Twelve patients with syphilis were treated weekly with injections of 1.44 g (2.4 X 10(6) IU) of benzathine penicillin G for up to 3 weeks. Almost daily, serum penicillin concentrations were measured by a sensitive microbiological agar cup method. An individual and interindividual variation was found. Concentrations below the recommended 0.018 micrograms/ml were found 7 days after the first or second injection in 5 samples. Shorter intervals between injections are recommended.

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