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Rapeseed Bee Pollen Alleviates Chronic Non-bacterial Prostatitis via Regulating Gut Microbiota.
Journal of the Science of Food and Agriculture 2023 July 25
BACKGROUND: Rapeseed bee pollen has been recognized as a critical treatment for chronic non bacterial prostatitis (CNP) and it also can modulate gut microbiota and improve gut health. This study aimed to explore the anti prostatitis effects of rapeseed bee pollen with or without wall disruption, and investigate the connection between this treatment and gut microbiota.
RESULTS: Our results reveal that rapeseed bee pollen can effectively alleviate chronic non bacteria prostatitis via selectively regulating gut microbiota, with higher doses and wall disrupted pollen showing greater efficacy. Treatment with a high dose of wall disrupted rapeseed bee pollen (WDH, 1.26 g/kg body weight) respectively reduced prostate wet weight and prostate index by approximately 32% and 36%, similar to the control group. Moreover, WDH treatment significantly reduced (p<0.05) the expression of proinflammatory cytokines (IL-6, IL-8, IL-1β and TNF-α), as confirmed by immunofluorescence with laser scanning confocal microscope. Our results show that rapeseed bee pollen can inhibit pathogenic bacteria and enhance probiotics, particularly in the Firmicutes-to-Bacteroidetes(F/B) ratio and the abundance of Prevotella (genus).
CONCLUSION: This is the first study to investigate the alleviation of rapeseed bee pollen on CNP through gut microbiota. Our results seem to provide a better understanding of developing rapeseed bee pollen as a complementary medicine. This article is protected by copyright. All rights reserved.
RESULTS: Our results reveal that rapeseed bee pollen can effectively alleviate chronic non bacteria prostatitis via selectively regulating gut microbiota, with higher doses and wall disrupted pollen showing greater efficacy. Treatment with a high dose of wall disrupted rapeseed bee pollen (WDH, 1.26 g/kg body weight) respectively reduced prostate wet weight and prostate index by approximately 32% and 36%, similar to the control group. Moreover, WDH treatment significantly reduced (p<0.05) the expression of proinflammatory cytokines (IL-6, IL-8, IL-1β and TNF-α), as confirmed by immunofluorescence with laser scanning confocal microscope. Our results show that rapeseed bee pollen can inhibit pathogenic bacteria and enhance probiotics, particularly in the Firmicutes-to-Bacteroidetes(F/B) ratio and the abundance of Prevotella (genus).
CONCLUSION: This is the first study to investigate the alleviation of rapeseed bee pollen on CNP through gut microbiota. Our results seem to provide a better understanding of developing rapeseed bee pollen as a complementary medicine. This article is protected by copyright. All rights reserved.
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