High-Dose Glucocorticoids for the Treatment of Sudden Hearing Loss.

Stefan K Plontke, Matthias Girndt, Christoph Meisner, Imma Fischer, Iris Böselt, Jan Löhler, Beatrice Ludwig-Kraus, Michael Richter, Jörg Steighardt, Bernd Reuter, Christoph Böttcher, Jörg Langer, Wolfram Pethe, Ingmar Seiwerth, Nebojsa Jovanovic, Wilma Großmann, Andrea Kienle-Gogolok, Andreas Boehm, Marcus Neudert, Marc Diensthuber, Andreas Müller, Stefan Dazert, Orlando Guntinas-Lichius, Joachim Hornung, Veronika Vielsmeier, Joachim Stadler, Torsten Rahne

NEJM Evid 2024 January

High-Dose Glucocorticoids for Sudden Hearing LossThis trial compared courses of high-dose intravenous prednisolone or high-dose oral dexamethasone versus standard-dose oral prednisone in adults with idiopathic sudden sensorineural hearing loss. At 30 days, systemic high-dose glucocorticoid therapy was not superior to a lower-dose regimen with respect to change in hearing threshold, and it was associated with a higher risk of side effects.

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