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Hepatitis A: detection by immune electron microscopy of a viruslike antigen associated with acute illness.

Science 1973 December 8
Spherical 27-nanometer particles were visualized in stools obtained from hepatitis A patients in the acute phase of the disease. The particle was serologically specific for this disease, and every hepatitis A patient tested demonstrated a serologic response to this antigen. The findings suggest that it is the etiologic agent of hepatitis A.

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