Add like
Add dislike
Add to saved papers

Effect of vitreous on morphologic characteristics of retinal pigment epithelial cells. A new approach to the study of proliferative vitreoretinopathy.

Normally, human retinal pigment epithelial (RPE) cells in confluent monolayers maintain a hexagonal to oval shape. However, when these monolayers were overlaid with autologous vitreous, the RPE cells elongated and migrated into the vitreous gel as bipolar fibrocytelike cells. We studied the effect of sodium hyaluronate and collagen individually. Retinal pigment epithelial cells overlaid with hyaluronate did not change their morphologic features. In contrast, when RPE monolayers were overlaid with a collagen gel, the cells changed from their normal epithelial characteristics to bipolar fibrocytelike cells that later migrated into the collagen gel. Exposure of RPE cells to vitreous may play a role in the pathogenesis of proliferative vitreoretinopathy.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app