We have located links that may give you full text access.
CASE REPORTS
JOURNAL ARTICLE
Cowden's disease (multiple hamartoma and neoplasia syndrome). A case report and review of the English literature.
Cowden's disease is a multisystem disease complex inherited as an autosomal dominant trait with incomplete penetrance and variable expressivity. Its mucocutaneous findings are the most characteristic feature of the syndrome and the key to its diagnosis. The findings of multiple facial trichilemmomas appear to be pathognomonic of the disease. Multiple extracutaneous hamartomas are a regular feature of Cowden's disease. The most important hamartomas to recognize include fibrocystic disease of the breast, thyroid goiters or adenomas, multiple polyposis of the gastrointestinal tract, and ovarian cysts. Although many developmental anomalies have been described in these patients, only adenoid facies and high-arched palates appear significant from a statistical standpoint. The most important feature of Cowden's disease, that which makes early recognition absolutely essential, is an increased prevalence of malignant neoplasia primarily in affected female patients, and principally involving the breasts and thyroid gland. All patients, however, must be screened for occult malignancies of all types. A detailed review of the English literature offers a basis for the formation of guidelines that should be helpful in making a diagnosis of the disease.
Full text links
Trending Papers
A Personalized Approach to the Management of Congestion in Acute Heart Failure.Heart International 2023
Potential Mechanisms of the Protective Effects of the Cardiometabolic Drugs Type-2 Sodium-Glucose Transporter Inhibitors and Glucagon-like Peptide-1 Receptor Agonists in Heart Failure.International Journal of Molecular Sciences 2024 Februrary 21
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app