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Journal Article
Research Support, Non-U.S. Gov't
Central nervous system amplification: its potential in the diagnosis of early multiple sclerosis.
Neurology 1982 April
Ability to record a sizable somatosensory evoked potential (SEP) in the absence of a recordable sensory nerve action potential (SNAP) suggests a normally occurring central nervous system amplifying process. Increments in SEP and SNAP amplitude with increasing stimulus strength between threshold and 2.5 times threshold (maximum) were compared. A threshold (40% of maximum stimulus) and 50% maximum stimulus, amplification measured 2.3 +/- 0.7 and 2.0 +/- 0.6, respectively. In 21 MS patients, the SEP at threshold stimulation was absent in 15, but normal in 5 of these at maximum stimulation. It is postulated that normal central amplification is markedly attenuated in MS, and this may be a sensitive indicator of early disease.
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