We have located links that may give you full text access.
Cavernous hemangioma of the liver: pathologic correlation with high-field MR imaging.
OBJECTIVE: MR imaging is used to characterize cavernous hemangiomas of the liver because these neoplasms have a long transverse relaxation time compared with normal liver parenchyma and other hepatic neoplasms. The purpose of this study was to correlate the pathologic findings of hemangiomas with their appearance on high-field MR images and with mean T2 relaxation time.
MATERIALS AND METHODS: Tissue cores were obtained by percutaneous needle biopsy of 14 cavernous hemangiomas, ranging in size from 1.0 to 10.9 cm. Mean relaxation time was determined from T2-weighted spin-echo MR images. Pathologic analysis included quantification of endothelial cells, identified by counterstaining to anti-factor VIII antibody.
RESULTS: We found an inverse relationship between the number of endothelial cells in the histologic specimen and the mean T2 value of the tumor (r = -.75; p < .002). Pathologic examination of tissue from three tumors with the shortest T2 relaxation times showed relatively greater amounts of connective tissue and more numerous but small and compressed vascular channels. Although the two hemangiomas less than 2 cm in diameter had T2 times less than 80 msec, no significant relationship between tumor size and relaxation time was found.
CONCLUSION: We conclude that T2 relaxation time of cavernous hemangioma is directly related to the collective size of its constituent vascular spaces. We found no statistically significant difference in measured T2 relaxation time and no difference in histologic appearance between hemangiomas smaller than 2 cm and larger tumors.
MATERIALS AND METHODS: Tissue cores were obtained by percutaneous needle biopsy of 14 cavernous hemangiomas, ranging in size from 1.0 to 10.9 cm. Mean relaxation time was determined from T2-weighted spin-echo MR images. Pathologic analysis included quantification of endothelial cells, identified by counterstaining to anti-factor VIII antibody.
RESULTS: We found an inverse relationship between the number of endothelial cells in the histologic specimen and the mean T2 value of the tumor (r = -.75; p < .002). Pathologic examination of tissue from three tumors with the shortest T2 relaxation times showed relatively greater amounts of connective tissue and more numerous but small and compressed vascular channels. Although the two hemangiomas less than 2 cm in diameter had T2 times less than 80 msec, no significant relationship between tumor size and relaxation time was found.
CONCLUSION: We conclude that T2 relaxation time of cavernous hemangioma is directly related to the collective size of its constituent vascular spaces. We found no statistically significant difference in measured T2 relaxation time and no difference in histologic appearance between hemangiomas smaller than 2 cm and larger tumors.
Full text links
Related Resources
Trending Papers
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment.Clinical Research in Cardiology : Official Journal of the German Cardiac Society 2024 April 12
Proximal versus distal diuretics in congestive heart failure.Nephrology, Dialysis, Transplantation 2024 Februrary 30
World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.American Journal of Hematology 2024 March 30
Efficacy and safety of pharmacotherapy in chronic insomnia: A review of clinical guidelines and case reports.Mental Health Clinician 2023 October
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app