Central serous chorioretinopathy in endogenous hypercortisolism.

OBJECTIVE: To examine the potential association of central serous chorioretinopathy with endogenous hypercortisolism (Cushing's syndrome).

DESIGN: Ophthalmologic survey of consecutively admitted patients with endogenous Cushing's syndrome.

SETTING: An eye clinic of a research center (National Eye Institute, Bethesda, Md).

PATIENTS: Sixty consecutive patients with confirmed endogenous Cushing's syndrome.

MAIN OUTCOME MEASURES: Findings from complete ophthalmologic evaluation.

RESULTS: Three (5%) of 60 patients had one or more episodes of appropriately documented central serous chorioretinopathy. In all cases, the episodes occurred during the period of hypercortisolism.

CONCLUSIONS: Central serous chorioretinopathy is an uncommon manifestation of endogenous Cushing's syndrome. Since central serous chorioretinopathy has been associated with other hypercortisolemic states, we suggest that glucocorticoids may play a role in the development of this disease.