COMPARATIVE STUDY
JOURNAL ARTICLE
Add like
Add dislike
Add to saved papers

Plasmacytoid monomorphic adenoma of salivary glands. Absence of myogenous differentiation and comparison to spindle cell myoepithelioma.

The immunohistochemical and ultrastructural features of two salivary gland monomorphic adenomas composed of plasmacytoid cells (so-called plasmacytoid myoepitheliomas) were studied to determine if the plasmacytoid cells contained detectable evidence of myogenous differentiation. The results were compared with the immunohistochemical profile of three salivary gland myoepitheliomas of spindle-cell type. The plasmacytoid tumors were each immunoreactive for vimentin, cytokeratin, S100 protein, and glial fibrillary acidic protein (GFAP). They were negative for muscle-specific actin (MSA), smooth-muscle actin (SMA), and desmin. Conversely, two of three spindle-cell myoepitheliomas were immunoreactive for MSA and SMA, in addition to vimentin, cytokeratin, and S100 protein. One tumor also contained focal positivity for desmin and GFAP, and a single spindle-cell tumor was vimentin-positive only. Ultrastructurally, plasmacytoid cells were characterized by focal desmosomes, basal lamina, and abundant intermediate cytoplasmic filaments. Dense bodies typical of smooth-muscle cells and actin-sized filaments were absent. Immunohistochemically and ultra-structurally, the plasmacytoid cells lack any evidence of myogenous differentiation and should not be considered a subtype of myoepithelioma.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app