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Purely cutaneous Rosai-Dorfman disease.

M Skiljo, E García-Lora, J Tercedor, E Massare, J Esquivias, V García-Mellado
Dermatology : International Journal for Clinical and Investigative Dermatology 1995
Sinus histiocytosis with massive lymphadenopathy is an entity that exceptionally appears as a purely cutaneous disease. We described 2 cases of this form with spontaneous involution. Histology showed a polymorphic infiltrate in the dermis and hypodermis composed of large histiocytes with lymphophagocytosis, neutrophils and plasma cells. Immunohistochemical stains demonstrated the positivity of histiocytes for protein S-100 and MAC 387.

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