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Sonic hedgehog: making the gradient.

D A Bumcrot, A P McMahon
Chemistry & Biology 1996 January
The amino-terminal peptide of Sonic hedgehog is a cell-tethered molecule, which nevertheless seems to provide a developmental signal that acts at a distance and has different effects depending on its concentration. Recent structural data suggest that zinc-dependent proteolysis may somehow be involved in Sonic hedgehog's function.

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