We have located links that may give you full text access.
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Development of a national prospective study of Alzheimer disease.
The purpose of this commentary is briefly to review the genetic, social, demographic, and environmental factors associated with Alzheimer disease with the specific purpose of planning an intervention to prevent or possibly delay the onset of disease. Complex disorders such as Alzheimer disease are the result of one or more genes and other contributing risk factors. For example, apolipoprotein E (APOE) genotypes can indicate a degree of susceptibility, but the gene is neither "necessary nor sufficient" to cause the disease. Thus, many potential risk factors remain to be identified. The association between Alzheimer disease and APOE also varies with age, genetic background, and ethnic group. While the use of APOE genotyping has provided a method to identify individuals at greatest risk of Alzheimer disease, how other factors modify the degrees of the APOE-related risk needs to be further investigated. Moreover, the effect of APOE on disease course and various noncognitive manifestations warrant scrutiny. Because risk prediction is not straightforward, practical issues related to developing a national strategy to prevent or delay the onset of Alzheimer disease require careful consideration, planning, and an organized interdisciplinary effort.
Full text links
Related Resources
Trending Papers
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Prevention and treatment of ischaemic and haemorrhagic stroke in people with diabetes mellitus: a focus on glucose control and comorbidities.Diabetologia 2024 April 17
Diagnosis and Management of Cardiac Sarcoidosis: A Scientific Statement From the American Heart Association.Circulation 2024 April 19
Eosinophilic Esophagitis: Clinical Pearls for Primary Care Providers and Gastroenterologists.Mayo Clinic Proceedings 2024 April
Essential thrombocythaemia: A contemporary approach with new drugs on the horizon.British Journal of Haematology 2024 April 9
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app