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JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Onchocerciasis: clinical presentation and host parasite interactions in patients of southern Sudan.
International Journal of Dermatology 1997 January
BACKGROUND: Onchocerciasis, an infection by the filarial nematode Onchoverca volvulus, is widely distributed in tropical Africa and of great dermatologic interest. This study analyses the dermatologic presentation and tries to determine the correlations between clinical disease and host parasite interactions in onchocerciasis patients of the Southern Sudan.
METHODS: We performed clinical and histopathologic investigations in patients with onchocerciasis in the Wau District, Bahr el Ghazal Province, Southern Sudan. As well as a detailed clinical skin examination, skin biopsies were taken, processed, and investigated for type and degree of host tissue response. Parasitologic, clinical, and histopathologic findings were evaluated.
RESULTS: Onchocerciasis appears with a variety of severe skin lesions. Central is a pruritic rash. Long-standing cases develop extensive pigmentary changes and impressive signs of skin tissue exhaustion. Cellular host tissue responses to degenerating skin microfilariae seem to play a key role in the development of skin pathology. The degree of host response appears to be inversely proportional to the host's microfilarial load.
CONCLUSIONS: Onchocerciasis represents a health problem of great dermatologic importance in Southern Sudan. The study results demonstrate clinical variations in onchocerciasis and provide support for the existence of a disease spectrum.
METHODS: We performed clinical and histopathologic investigations in patients with onchocerciasis in the Wau District, Bahr el Ghazal Province, Southern Sudan. As well as a detailed clinical skin examination, skin biopsies were taken, processed, and investigated for type and degree of host tissue response. Parasitologic, clinical, and histopathologic findings were evaluated.
RESULTS: Onchocerciasis appears with a variety of severe skin lesions. Central is a pruritic rash. Long-standing cases develop extensive pigmentary changes and impressive signs of skin tissue exhaustion. Cellular host tissue responses to degenerating skin microfilariae seem to play a key role in the development of skin pathology. The degree of host response appears to be inversely proportional to the host's microfilarial load.
CONCLUSIONS: Onchocerciasis represents a health problem of great dermatologic importance in Southern Sudan. The study results demonstrate clinical variations in onchocerciasis and provide support for the existence of a disease spectrum.
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