We have located links that may give you full text access.
Journal Article
Review
5q-, twenty-five years later: a synopsis.
Cancer Genetics and Cytogenetics 1997 March
Twenty-five years have elapsed since the first case of del(5q) was discovered in this laboratory. It was reported in 1974 with other subsequently found cases. As the sole anomaly or together with other chromosome changes, deletions of the long arm of 5 have been found in a large variety of hematologic disorders, but especially in myelodysplastic syndromes (MDS) and in acute myelogenous leukemia (AML). Deletions of 5q are the most frequent chromosome anomaly in therapy-induced myelodysplasia/AML. A clinically distinct entity is the 5q- syndrome in which 5q- is the only change in which female sex prevails. Leukemic transformation is low and survival relatively long. Although the myeloid lineage is predominantly affected in 5q- associated disorders, lymphoid disorders, including 5q- acute lymphoblastic leukemia (B and T) exist and show male predominance. The underlying molecular lesions in 5q- myeloid disorders are still largely unknown. There seems to be a critical segment in 5q31, and preliminary studies suggest the inactivation of one or more genes within that region, deletions of which at the molecular level may be heterogeneous.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Diagnosis and Management of Cardiac Sarcoidosis: A Scientific Statement From the American Heart Association.Circulation 2024 April 19
Essential thrombocythaemia: A contemporary approach with new drugs on the horizon.British Journal of Haematology 2024 April 9
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app