We have located links that may give you full text access.
CLINICAL TRIAL
COMPARATIVE STUDY
JOURNAL ARTICLE
Quality-switched ruby laser treatment of solar lentigines and Becker's nevus: a histopathological and immunohistochemical study.
OBJECTIVE: A histopathological and immunohistochemical study was initiated to assess changes in benign human pigmented skin lesions after quality switched ruby laser (QSRL) irradiation.
METHOD: A total of 196 solar lentigines on 8 patients' forearms were irradiated in vivo, 13 biopsies were taken. Hematoxylin-eosin staining and immunohistochemical techniques using anti-S-100 and Fontana-Masson stainings, as well as cryosections stained with nitroblue tetrazolium chloride (NBTC), were employed for the evaluation of the specimens.
RESULTS: Immediately after QSRL impact selective photothermal damage (vacuolization) of all pigmented epidermal and basal melanocytes, keratinocytes, superficial dermal melanocytes and melanophages could be observed in solar lentigines. Cryosections stained with NBTC featured minimal thermal damage of the surrounding tissue. One Becker's nevus was also exposed to the QSRL, biopsies were taken before and immediately after QSRL exposure. In this lesion, superficially located pigments were selectively damaged, but a fair amount of pigmented cells in adnexal structures persisted throughout this single course of QSRL treatment. Recurrence of lentigines was not observed. In Becker's nevus, following initial fading of the lesion, clinically reactive hyperpigmentation occurred 4 weeks later.
CONCLUSION: We found that pigmented lesions featuring a moderate amount of pigment exclusively in and around the basal cell layer, like solar (actinic) lentigo, can be successfully removed by a single QSRL exposure selectively damaging epidermal and basal pigmented structures. Further investigations concerning QSRL treatment of dermally pigmented skin lesions have to be initiated.
METHOD: A total of 196 solar lentigines on 8 patients' forearms were irradiated in vivo, 13 biopsies were taken. Hematoxylin-eosin staining and immunohistochemical techniques using anti-S-100 and Fontana-Masson stainings, as well as cryosections stained with nitroblue tetrazolium chloride (NBTC), were employed for the evaluation of the specimens.
RESULTS: Immediately after QSRL impact selective photothermal damage (vacuolization) of all pigmented epidermal and basal melanocytes, keratinocytes, superficial dermal melanocytes and melanophages could be observed in solar lentigines. Cryosections stained with NBTC featured minimal thermal damage of the surrounding tissue. One Becker's nevus was also exposed to the QSRL, biopsies were taken before and immediately after QSRL exposure. In this lesion, superficially located pigments were selectively damaged, but a fair amount of pigmented cells in adnexal structures persisted throughout this single course of QSRL treatment. Recurrence of lentigines was not observed. In Becker's nevus, following initial fading of the lesion, clinically reactive hyperpigmentation occurred 4 weeks later.
CONCLUSION: We found that pigmented lesions featuring a moderate amount of pigment exclusively in and around the basal cell layer, like solar (actinic) lentigo, can be successfully removed by a single QSRL exposure selectively damaging epidermal and basal pigmented structures. Further investigations concerning QSRL treatment of dermally pigmented skin lesions have to be initiated.
Full text links
Trending Papers
A Personalized Approach to the Management of Congestion in Acute Heart Failure.Heart International 2023
Potential Mechanisms of the Protective Effects of the Cardiometabolic Drugs Type-2 Sodium-Glucose Transporter Inhibitors and Glucagon-like Peptide-1 Receptor Agonists in Heart Failure.International Journal of Molecular Sciences 2024 Februrary 21
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app