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Proliferation marker Ki-S5 as a diagnostic tool in melanocytic lesions.
Journal of the American Academy of Dermatology 1997 August
BACKGROUND: A discrimination between benign and malignant melanocytic lesions is not always possible by conventional histology.
OBJECTIVE: Our purpose was to determine the proliferative activity in various types of melanocytic neoplasms and to appraise its value as a diagnostic adjunct.
METHODS: The growth fraction was assessed immunohistochemically in 398 melanocytic lesions by means of the monoclonal antibody Ki-S5 directed to the Ki-67 antigen. In this way, a cut-off level was defined and applied to 112 lesions of equivocal histology. The revised diagnoses were correlated to the clinical courses.
RESULTS: Common nevi, Spitz nevi, and melanomas exhibited significantly different proliferation indices and distinctive distribution patterns of cycling cells. In agreement, malignancy diagnosed on the basis of a growth fraction greater than 5% was confirmed by disease progression in 68% of our cases with uncertain diagnosis.
CONCLUSION: Determination of the proliferative activity in melanocytic lesions may usefully complement conventional histology to improve diagnostic accuracy.
OBJECTIVE: Our purpose was to determine the proliferative activity in various types of melanocytic neoplasms and to appraise its value as a diagnostic adjunct.
METHODS: The growth fraction was assessed immunohistochemically in 398 melanocytic lesions by means of the monoclonal antibody Ki-S5 directed to the Ki-67 antigen. In this way, a cut-off level was defined and applied to 112 lesions of equivocal histology. The revised diagnoses were correlated to the clinical courses.
RESULTS: Common nevi, Spitz nevi, and melanomas exhibited significantly different proliferation indices and distinctive distribution patterns of cycling cells. In agreement, malignancy diagnosed on the basis of a growth fraction greater than 5% was confirmed by disease progression in 68% of our cases with uncertain diagnosis.
CONCLUSION: Determination of the proliferative activity in melanocytic lesions may usefully complement conventional histology to improve diagnostic accuracy.
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