JOURNAL ARTICLE
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Vascular abnormalities in scleroderma.

Vascular abnormalities represent a fundamental event in the pathogenesis of systemic sclerosis. This review focuses on key observations that support this view and builds a framework with which to clarify our understanding of how endothelial cell damage may trigger a self-fueling process ending in pathological tissue fibrosis in those susceptible to scleroderma. The studies reviewed in this article pertain to systemic sclerosis patients.

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