CASE REPORTS
JOURNAL ARTICLE
REVIEW
Add like
Add dislike
Add to saved papers

The syndrome of inappropriate secretion of antidiuretic hormone: an unusual presentation for childhood craniopharyngioma: report of three cases.

Neurosurgery 1998 April
OBJECTIVE AND IMPORTANCE: Childhood craniopharyngiomas may present with variable endocrine dysfunctions. However, hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone has never been reported. We describe three children with craniopharyngioma who presented with hyponatremia.

CLINICAL PRESENTATION: Three children had hyponatremia at presentation, two of whom had experienced generalized seizures. Urine sodium levels measured in two patients were abnormally high. Neuroimaging tests, including computed tomography and magnetic resonance imaging, showed a large partially calcified and partially cystic craniopharyngioma in the sellar/suprasellar location.

INTERVENTION: Intake of fluids was restricted for each patient, with improvement of hyponatremia, and each patient subsequently underwent a successful tumor resection. Postoperatively, all patients developed panhypopituitarism, including diabetes insipidus, and needed multiple hormonal replacement therapy.

CONCLUSION: Endocrine dysfunctions at diagnosis are commonly associated with childhood craniopharyngiomas, but the association of the syndrome of inappropriate secretion of antidiuretic hormone with craniopharyngioma has never been reported. Craniopharyngiomas should be included as a possibility in making the differential diagnosis of the syndrome of inappropriate secretion of antidiuretic hormone in children.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app